Recipient APCs are necessary and sufficient for CD8 + T-cell-mediated GVHD ... the treatment or prevention of GVHD. In MHC-mismatched GVHD mediated by CD4 + T cells, direct cognate interactions ...

Three days post viral infection CD8 T cells (red) re-arrest with antigen presenting cells (cyan), where they are supplied with IL-2 by CD4 T cells (yellow), which migrate in a stop and go pattern.

CD4+ and CD8+ T cells accumulate in the skin of patients with psoriasis. These cells are also identified by markers of activation (e.g., increased IL-2 receptors and HLA-DR surface molecules) and ...