CDK7 does this in two ways: It switches on other enzymes known as kinases, including CDKs 1, 2, 4 and 6, which kick-start cells to divide and multiply. It also regulates gene expression in ways ...

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a study led by scientists at Washington State University.

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a new study. Importantly, the researchers also found that ...

While that’s important during human development and for normal cell function, CDK7 can be exploited by cancer cells to drive runaway growth. In recent years, scientists have discovered that the ...

Eli Lilly took a CDK7 inhibitor into human testing in 2019 but stopped the trial over a lack of efficacy. Syros Pharmaceuticals dropped one asset, SY-1365, and another, SY-5609, is on the backburner.

Recursion is advancing REC-617, a promising reversible, non-covalent CDK7 inhibitor, showing potential in treating advanced solid tumors with positive interim phase 1 data. Read more here.

Prioritizing Development of SY-5609, Its Oral CDK7 Inhibitor, and Discontinuing Further Development of SY-1365, Its Intravenous CDK7 Inhibitor Expects to Initiate Phase 1 Trial of SY-5609 in First ...

Q901 is a novel highly selective CDK7 inhibitor Q901 is ready for dose escalation study in the U.S. for the treatment of selected advanced solid tumors (NCT 05394103) The phase 1/2 study of Q901 ...

“This study reveals that CDK7 controls RB1 function—a finding that could open doors to new ways of therapeutically targeting RB1,” said Taatjes. Meanwhile, CDK7’s other role—of kick-starting enzymes ...

TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network. Science Advances, 2025; 11 (9) DOI: 10.1126/sciadv.adr9660 ...