The Chinese company’s saRNA therapy is intended to increase expression in the p21 tumour suppressor gene and acts as a cyclin-dependent kinase inhibitor (CDKI). Through this, p21 typically works ...

The universal cell-cycle inhibitor p21 Cip1/WAF1 is phosphorylated and localized in the cytoplasm in Her2/neu-overexpressing breast cancers as a result of its physical association with the ...