To grow, cancer tumors must hijack the immune system for their needs. One of the main tricks that most tumors use is to ...

One of their key attributes is their mobility to sites of inflammation, infection, and tumors. This trait garnered the attention of researchers who developed therapies to leverage macrophages’ ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

Fig. 1 | Eliminating tumors with macrophage–drug conjugates. ICD, immunogenic cell death. The process is enhanced by the drug component, which directly kills cancer cells and creates debris for ...

Carisma Therapeutics is developing a unique, differentiated immuno-oncology (IO) treatment for solid tumors based on chimeric antigen receptor macrophages (CAR-M). Current IO treatments have ...

Researchers from Moffitt Cancer Center have found a new way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure, or MARCO. Their study ...