Researchers at University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA ...

The resulting experimental mouse is hemizygous for Cre and homozygous for loxP (D). This is the necessary genotype required to conditionally knock out the target gene in the specific tissue. Laura is ...

When Cre recombinase (red circle) is introduced, either as a transgene by crossing into a mouse line carrying the targeted gene locus or on a viral vector, the DNA between the loxP sites (red ...

Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA sequence loxP, which is its target. This vector allows the creation of ...

Cre-loxP organisms are generally produced by separately creating Cre-lineage and loxP-lineage individuals that contain the ...