Designed to target cyclin E-driven cancers, NKT3964 is an oral small molecule offering substantial promise for addressing a ...

γ-herpesvirus genomes encode an abundance of homologues of cellular factors, including cyclin and Bcl-2. These viral homologues differ from their cellular counterparts in that the viral proteins ...

Figure 1: Recruitment of cyclin E/Cdk2/Xic1 and SCF to replication origins. The third role of cyclin E/Cdk2 in Xic1 degradation is the recruitment of SCF components to chromatin 1, which is likely ...

"We are excited to outline a clear path for Zentalis to bring azenosertib to patients with Cyclin E1+ PROC,” said Ingmar Bruns, M.D., Chief Medical Officer. "In a patient population with a clear unmet ...

“The clinical data we recently presented supports rapid advancement of azenosertib as a monotherapy therapy for patients with Cyclin E1+ PROC, and the continued development of azenosertib in ...

Press Release Circle Pharma, a clinical-stage biopharmaceutical company focused on developing cell-permeable macrocycle therapeutics, today announced a late-breaking poster presentation at the ...