Furthermore, it has been demonstrated that in vivo expression is sustained for several months without detectable pathology. In the original lentivirus vectors described by Naldini et al (Naldini et al ...

but earlier gene therapy approaches have been unable to incorporate enough of the LCR to achieve regulated expression. Now, researchers have found that a lentiviral vector can transduce a large ...

The investigators showed that lentiviral transduction was enhanced by CsH and led to therapeutic levels of expression of HbAs3. "In addition to its ability to enhance the efficiency of ...

Researchers successfully use a nonviral, piggyBac transposon system to introduce a transgene into cynomolgus monkeys.

Among these, lentivirus-based vectors, derived from the HIV-1 retrovirus, are of growing interest in gene and cell therapy, particularly in immuno-oncology, due to their ability to infect dividing ...

AstraZeneca has entered the “off-the-shelf” cell therapy space, penning a $1 billion deal to acquire EsoBiotec and its lentiviral vector platform. The deal will see AstraZeneca scoop up all ...