Lentiviral transduction is a popular delivery platform for applications such as CAR-T cell engineering or CRISPR-Cas9 gene editing, as it can transduce both dividing and non-dividing cells and ...

The risk of the generation of RCL through uncontrolled recombination in vector productions was largely addressed by engineering split plasmid systems for the generation of lentiviral particles ...

lentiviral vectors (developed from aforementioned complex retroviruses) have properties that overcome limitations of simple retroviral vectors. These include higher stability of viral particles ...

Vectors derived from lentiviruses have provided a huge advancement in technology and seemingly offer the means to achieve significant levels of gene transfer in vivo. As the particles are often ...

Leprechaun is the only system that can accurately determine the viral titer of lentiviruses by identifying particles of the right size and structure. It can be used to count lentiviruses in crude ...

Scientists show that envelope proteins derived from the endogenous feline virus RD114 provide a versatile and effective method to pseudotype lentiviral vectors. Therapeutic lentiviral vectors are ...

The GPS systems of honing turtles reminded the founder, president, and CSO of Kelonia, Kevin Friedman, PhD, of the lentiviruses he has been programming to navigate the body to find a specific ...

The new QIAcuity CGT dPCR assays, including eight different wet-lab verified lentiviral targets, are designed for viral vector genome titration (measuring the amount of therapeutic virus particles) ...

Lentiviral packaging genes are provided on separate plasmids, so the pseudo lentiviral particles are replication deficient. Despite their advantages, however, LV vectors are associated with a ...

Autologous HSCs were transduced with CD68-ET3-LV — a lentiviral vector including a new F8 transgene (ET3) with a myeloid-directed CD68 promoter — either without transduction enhancer (group 1 ...

It supports standardized titer quantification from lentivirus particles, promotes robust QC and improved operating procedures, and is ideal for drug development and manufacturing in CGT.