Densitometric analysis was used to determine the intensity of p53, phospho-p53, and MDM2 bands. Results: Approximately 38.7% of the lung cancer patients examined had an association with wood smoke ...

Blocking the MDM2–p53 interaction to reactivate wild-type p53 function is therefore a promising cancer therapeutic strategy, especially in this setting. At Boehringer Ingelheim, we have ...

These proteins, called MDM2 and MDMX, become overactive in cancer and break down p53. Researchers have developed drugs to block MDM2 or MDMX, but targeting just one of these proteins is often not ...

It also develops APG-2575, an oral administered Bcl-2 selective inhibitor for hematologic malignancies and solid tumors; APG-115, an oral small molecule inhibitor of the MDM2-p53 protein-protein ...