Furthermore, Mdm2 not only functions as an E3 ligase in the degradation of p53, but is also involved in exporting p53 out of the nucleus before its degradation.

Multiple E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) that regulate essential cancer-related proteins were ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...