Nevertheless, MdmX has been reported to migrate at M r 70–90K (depending on the method used), and upon in vitro translation it co-migrates with Mdm2 at M r ∼ 90K on SDS–polyacrylamide gels 9.

It focuses on its lead product candidate, ALRN-6924, which is a cell-permeating peptide that disrupts the interaction of p53 suppressors MDM2 and MDMX with tumor suppressor p53 to reactivate tumor ...

However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...