A review paper published last year in European Journal of Medicinal Chemistry characterized Myc as the “oncogene from ...

The researchers discovered ecDNA to be surprisingly common in pancreatic tumors, particularly for oncogenes like MYC, which drives cancer growth and metabolism. “… we provide a detailed ...

With the realization that the gross genetic abnormalities that activated MYC in cancer universally led to deregulated expression of the intact coding region, a series of new questions arose.

A new study published in Life Science Alliance reveals a key genetic connection between cancer susceptibility and tissue ...

Chodosh and colleagues developed a transgenic mouse model of breast cancer that more closely resembles a human epithelial tumour type — as MYC amplification occurs in 5–15% of human breast ...

By isolating the key DNA sequence from the virus and implanting it in embryos (along with, in varying combinations, the cancer-promoting oncogenes myc and ras), they created a mouse susceptible to ...

DDX54 activates the Jak-Stat3, MYC, and NF-κB pathways in lung cancer cells to increase CD38 and CD47 expression (A-G). This ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

which cause therapeutic vulnerabilities in breast cancer. Our current research specifically focuses on therapeutic strategies aiming to exploit MYC oncogene-induced vulnerabilities and therapeutically ...

"Right now, in cancer treatment, 'combination' is pretty ... exhibited high PRMT5 expression alongside elevated levels of MYC, MYB, and Lenvatinib target genes. These findings suggest that ...