A review paper published last year in European Journal of Medicinal Chemistry characterized Myc as the “oncogene from ...

To prevent the third most lethal cancer in Spain from becoming the second by 2030, clinicians are seeking to increase the ...

With the realization that the gross genetic abnormalities that activated MYC in cancer universally led to deregulated expression of the intact coding region, a series of new questions arose.

Chodosh and colleagues developed a transgenic mouse model of breast cancer that more closely resembles a human epithelial tumour type — as MYC amplification occurs in 5–15% of human breast ...

Researchers at Karolinska Institutet identified a super-enhancer region upstream of the MYC gene essential for tumor development and tissue repair. Cancer has often been described as a wound that ...

DDX54 activates the Jak-Stat3, MYC, and NF-κB pathways in lung cancer cells to increase CD38 and CD47 expression (A-G). This creates a cancer microenvironment that contributes to cancer development (H ...

By isolating the key DNA sequence from the virus and implanting it in embryos (along with, in varying combinations, the cancer-promoting oncogenes myc and ras), they created a mouse susceptible to ...

which cause therapeutic vulnerabilities in breast cancer. Our current research specifically focuses on therapeutic strategies aiming to exploit MYC oncogene-induced vulnerabilities and therapeutically ...