In parallel with the hunt to identify MYC target genes and their mechanisms of regulation, there was an equally voracious appetite to identify and understand the main biological activity and ...

A review paper published last year in European Journal of Medicinal Chemistry characterized Myc as the “oncogene from ...

Yet our study suggests some such compounds may specifically target cancer and regenerative cells—while sparing normal tissue," says Kaur Sur. The MYC super-enhancer region on chromosome 8q24 ...

In responding models, AUTX-703 decreases expression of MYC target genes. In models that undergo epithelial differentiation, AUTX-703 enhanced expression of antigen presentation genes, suggesting ...

The team concludes, "Taken together, these results unveil the inhibitory role of miR-377 in MYC function within PCa, thereby suggesting its potential as a therapeutic target for the treatment of ...