A review paper published last year in European Journal of Medicinal Chemistry characterized Myc as the “oncogene from ...

In parallel with the hunt to identify MYC target genes and their mechanisms of regulation, there was an equally voracious appetite to identify and understand the main biological activity and ...

A new study published in Life Science Alliance reveals a key genetic connection between cancer susceptibility and tissue ...

Their findings demonstrate that miR-377 effectively targets MYC mRNA, as confirmed by luciferase assay and Real-time PCR. They observed a significant reduction in BCL-2 and CDK4 expression ...

These c-mods alter the oncogenic functions of the ‘holy grail’ targets MYC and beta catenin through novel mechanisms of action that leverage our unique expertise in condensate biology”, said ...

Our current research specifically focuses on therapeutic strategies aiming to exploit MYC oncogene-induced vulnerabilities and ... as well as patient tumor-derived explants for ex vivo target ...

Researchers have uncovered a promising therapeutic target for adenoid cystic carcinoma (ACC), a rare cancer of the salivary glands with few treatment options. The study, "PRMT5 inhibition has a ...

Dewpoint will present two posters at AACR Condensate modulators (c-mods) demonstrate robust anti-tumor effects across multiple types of cancer C-mods modulate the oncogenic function of historically ...