In parallel with the hunt to identify MYC target genes and their mechanisms of regulation, there was an equally voracious appetite to identify and understand the main biological activity and ...

Parabilis Medicines (formerly Fog Pharmaceuticals), a clinical-stage biopharmaceutical company committed to creating ...

A review paper published last year in European Journal of Medicinal Chemistry characterized Myc as the “oncogene from ...

Their findings demonstrate that miR-377 effectively targets MYC mRNA, as confirmed by luciferase assay and Real-time PCR. They observed a significant reduction in BCL-2 and CDK4 expression ...

Yet our study suggests some such compounds may specifically target cancer and regenerative cells—while sparing normal tissue," says Kaur Sur. The MYC super-enhancer region on chromosome 8q24 ...

In responding models, AUTX-703 decreases expression of MYC target genes. In models that undergo epithelial differentiation, AUTX-703 enhanced expression of antigen presentation genes, suggesting ...

These c-mods alter the oncogenic functions of the ‘holy grail’ targets MYC and beta catenin through novel mechanisms of action that leverage our unique expertise in condensate biology”, said ...

BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.