We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

NOTCH signaling influences these traits through interactions with other pathways like TGF-β, WNT, and hypoxia signaling. The canonical NOTCH pathway maintains resistant cell populations ...

The study further examines the interplay between ubiquitination and key signaling pathways, including Notch, Wnt/β-catenin, Hedgehog, and Hippo-YAP, which regulate stem-like properties in cancer ...