When p53 malfunctions, the result is often cancer. Learning about how p53 works has not only deepened how scientists understand cancer, but also provided promising avenues for new treatments.

Researchers found that the loss of p53 function led to the secretion of IL-34 directly. But the blockade of IL-34 restrained ...

We also demonstrated that, in vivo when the ligand-liposome encapsulated wt p53 was injected I.V., preexisting SCCHN and prostate cancer xenografts completely regressed after radiotherapy.

Shelley L. Berger, PhD, FAACR, has been recognized for her outstanding contributions to cancer research by the American Association for Cancer Research (AACR) with the 2025 AACR-Women in Cancer ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 2010;468(7323):572-5. 5. Morris JPt, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS ...