Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or ...

But the blockade of IL-34 restrained the growth of liver cancer with p53 inactivation, and thus prolonged the survival of ...

DePinho and colleagues have shown that in the cells of these mice, senescence occurs when telomeres become too short. This senescence induction depends upon the action of the tumor suppressor p53.

For animal requests, please contact the mouse colony manager, Janelle Simon ... Modeling the therapeutic efficacy of p53 restoration in tumors. Cell. 2006;127(7):1323-34. 2. Ventura A, Kirsch DG, ...

Once everybody got on the same page, the community settled on a common name: p53. “The field looked at this and didn’t know what to make of it,” Levine said. “Because it wasn’t isolated like an ...