The scientists used AI technology to design proteins that would activate a cell signaling language called Notch, which is ...

A collaborative team from the Rosalind Franklin Institute, the University of Oxford, and Diamond Light Source has developed a breakthrough method that makes it possible to image very small proteins ...

For their analysis, the team focused on hydrogen bonds, which are weak bonds that the protein forms internally between the atoms in its amino acids and with the water surrounding it. These bonds are ...

They sketched out a made-up 3-D protein — something that did not exist in nature — and asked Rosetta to come up with an amino acid sequence that would fold into that structure. It worked.

A protein folds itself into a structure that determines how it functions and binds to other molecules in the body. These structures determine many aspects of human health and disease.

A Perspective on Protein Structure Prediction Using Quantum Computers. Journal of Chemical Theory and Computation, 2024; 20 (9): 3359 DOI: 10.1021/acs.jctc.4c00067 ...

The three scientists had been awarded the 2024 Nobel Prize for Chemistry for their “computational work on protein design and structure.” While AlphaFold and the subsequent AI revolution in biology ...

MassiveFold version 1.2.5, developed in Bash and Python 3, combined AlphaFold’s structure prediction capabilities with enhanced sampling through either AFmassive or ColabFold and optimized ...

Multiple PNMA2 proteins had spontaneously self-organized into 12-sided complexes that bore a striking resemblance to the geometric protein shells of some viruses. One of the immune system’s healthy ...