Once activated, Ras can do a variety of things. In this example, it activates an enzymatic cascade of MAP kinases ... activates an enzyme called a kinase. Learn how kinases initiate a signaling ...

Vividion Therapeutics has dosed the first subject in a Phase I trial of an oral inhibitor, VVD-159642, aimed at treating ...

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS/MAPK ...

Using this technique, they were able to identify known and novel protein interactions linking the epidermal growth factor receptor with the Ras/MAP kinase signaling pathway (see p. 1193).

The mitogen-activated protein kinase (MAPK) pathway is a central signaling cascade ... it can drive tumor development and growth. RAS is the most frequently mutated oncogene in cancer, with ...