Complement deficiencies in C1q, C2 and C4 cause SLE, but these are responsible for ... Complex models of disease risk will incorporate multiple genetic elements, as well as clinical and ...

Incurable Autoimmune Disease Systemic Lupus Erythematosus (SLE): New Genetic Findings Open Up Perspectives for Future Therapeutic Approaches Jan. 14, 2024 — Systemic lupus erythematosus (SLE ...

Systemic lupus erythematosus is an autoimmune disease for which a number of susceptibility loci exist, but the precise genes and mutations involved remain unclear. In October 28 advanced online Nature ...

Circulating DCs are decreased in SLE; this is thought to be due to enhanced migration into peripheral affected tissues. While there is variability between in vitro studies, SLE DCs exhibit an ...

SLICC will strive to incorporate African centers in future multicenter observational cohort studies and will also investigate methods to enhance the dissemination of SLE research findings from Africa.

To identify factors that increase the risk of renal involvement and its progression to ESRD in SLE, Alarcón et al. examined socioeconomic–demographic, clinical and genetic variables in a ...