T cells may be broadly classified as either helper T cells (Th cells, CD4+) or cytotoxic T cells (Tc cells, CD8+). In 1986, T.R. Mosmann, R.L. Coffman, and colleagues observed that individual clones ...

primarily through the rapid production of anti-viral T cells. Specifically, when a virus is detected, T Helper 1 (Th1) cells are generated to facilitate an inflammatory response needed to ...

T-cells within the small intestine lamina propria, particularly T helper 1 (Th1) cells, prevent the development of cancer in the small intestine. Lower T-cell counts were observed among AFD-fed ...

Soquelitinib has been shown to affect T cell differentiation and induce the generation of Th1 helper cells while blocking the development of both Th2 and Th17 cells and production of their ...

shifting the TME to a more immune-permissive Th1/M1 state,” said Mary Janatpour, Senior Vice President of Biology at Spotlight Therapeutics. “This strategy is designed to facilitate T cell ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by ...

“The data from the Phase 1/1b clinical trial of soquelitinib in patients with T cell lymphoma continues to demonstrate strong indications of anti-tumor activity in a significant number of ...