Wnt ligands bind to Frizzled receptors, stabilizing β-catenin, which accumulates in the cytoplasm and enters the nucleus. In the nucleus, β-catenin activates downstream genes like c-Myc and ...

“We found that organoids bearing MYC on extrachromosomal DNA could shift their dependency on WNT,” explained Antonia Malinova, PhD, co-first author and a former PhD student at the University ...