The pathway that the researchers targeted is called the mTOR signaling pathway. It regulates cell metabolism, growth, proliferation and survival, and also plays an important role in fetal growth ...

Panelists discuss how investigational therapies beyond Janus kinase (JAK) inhibition, including epigenetic modulation, telomerase inhibition, PI3K/AKT/mTOR pathway inhibition, immune modulation, TGF-β ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways ... on the PI3K pathway and are sensitive to specific inhibitors of ...

More information: Sarah A. Wedemeyer et al, Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan, Nature Aging (2025). DOI: 10.1038/s43587-024-00801 ...

In particular, the mechanistic target of rapamycin (mTOR) pathway has been tied to multiple ... Animal studies have demonstrated that decreased mTOR signaling extends lifespan by up to 19 percent ...