Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

BRCA1 mutations are rare in prostate cancer, with only 0.44% showing pathogenic variants. BRCA2 mutations appear more significant, occurring in 6% of germline tests. Findings question whether ...

BRCA1 or BRCA2 genes are more common in young women, and these mutations increase cancer risk by as much as 84%. Six percent of all breast cancer patients carry BRCA gene mutations, but in ...

Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination. Nature, 2024; 634 (8033): 482 DOI: 10.1038/s41586-024-07910-2 ...

The team evaluated 2004 women with BRCA1 and 484 with BRCA2 sequence variations from 59 centers in 11 countries, including the United States, Canada, Poland, Norway, Israel, Italy, and the Bahamas ...

It's a gene commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...

Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants. Journal of Clinical Oncology, 2022; DOI: 10.1200/JCO.21.02112 ...

Results Of 3,882 BRCA1 and 1,509 BRCA2 mutation carriers, 53% and 71%, respectively, had ever used hormonal contraceptives for at least 1 year (median cumulative duration of use, 4.8 and 5.7 years, ...