Nature

Augmented transgene expression in transformed cells using a parvoviral hybrid vector

Autonomous parvoviruses possess an intrinsic oncotropism based on viral genetic elements controlling gene expression and genome replication. We constructed a hybrid vector consisting of the H1 ...
News Medical

Engineering rotavirus-based vaccine vectors expressing SARS-CoV-2 spike epitopes

In a recent study posted to the bioRxiv* preprint server, researchers proposed rotavirus (RV)-based vaccine vectors with the potential for developing polyvalent vaccines targeting multiple enteric ...
News Medical

Researchers report that vectored expression of a high-affinity ACE2 microbody protein establishes a high degree of protection from SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers evaluated the use of receptor decoys for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on soluble forms of ...
ascopubs.org

Systematic assessment of LCMV based vaccine vectors expressing melanocyte differentiation antigens in human in vitro assays and in mouse melanoma models.

Human model to predict the outcome of cancer vaccine clinical trials. This is an ASCO Meeting Abstract from the 2019 ASCO Annual Meeting I. This abstract does not include a full text component.
ascopubs.org

NEBULA: A multicenter phase 1a/b study of a tumor-selective transgene-expressing adenoviral vector, NG-641, and nivolumab in patients with metastatic or advanced epithelial tumors.

ZENYTH-ESO: Master protocol to assess the safety and recommended phase II dose of next generation NY-ESO-1-specific TCR T-cells in HLA-A*02 patients with synovial sarcoma and myxoid/round cell ...