LOS ANGELES — Emma Heming Willis is arguably the country's most famous caregiver right now. She's talked at length about her husband Bruce Willis's frontotemporal dementia (FTD) diagnosis and how it twisted and tangled her happy life into something devastating.

Frontotemporal dementia or frontotemporal degeneration (FTD) refers to a range of disorders that impact the brain’s frontal lobes (regions behind forehead) or its temporal lobes (regions behind ears). These areas of the brain are commonly associated with personality, behavior and language.

In August, Bruce Willis’ wife, Emma Heming Willis told Diane Sawyer her husband is now living in a “second home” near his primary residence, so he can get 24-hour care. She also said Bruce Willis’ brain was “failing him,” and the “Die Hard” actor was losing the ability to communicate.

Asked how she feels about outside opinions on her family’s choices, Emma Heming Willis didn’t mince words: “F—k ‘em.”

This first-in-class ASO replicates the protective effects of naturally occurring CD33 loss-of-function variants, which are associated with increased resilience to neurodegenerative disease, reduced neuroinflammation,

Although amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). are very different diseases, they have something in common.. | Cell And Molecular Biology