“ANCA-associated vasculitis is associated with increased early mortality and a high risk of end-stage renal disease,” Peter A. Merkel, MD, MPH, chief of rheumatology and a professor of medicine and ...

Exposure of the fetus to excess glucocorticoids leads to long-term programming of the function of the hypothalamic–pituitary–adrenal (HPA) axis and the behaviour of the organism A number of ...

Glucocorticoids, the hormones released into the blood by the adrenal glands, are essential for survival, but prolonged exposure to high glucocorticoid levels — such as during chronic stress — has ...

Inhaled and oral glucocorticoids are associated with structural changes in the brain that may help explain some of the neurological and psychological side effects seen with these drugs, a new study ...

Glucocorticoids (GCs) are widely prescribed anti-inflammatory agents, but their chronic use leads to undesirable side effects such as excessive expansion of adipose tissue. We have recently shown that ...

Deciphering how the GR forms oligomers — through the binding of several subunits — opens a crucial avenue for developing more selective drugs. These new drugs could modulate this association and thus ...

This glucocorticoid is a steroid hormone that is created from cholesterol and is released from the adrenal cortex within the zona fasciculata layer. The hypothalamus-pituitary-adrenal (HPA) axis works ...

Children and adolescents with congenital adrenal hyperplasia, or CAH, diagnosed early via a neonatal screening program and treated with hydrocortisone had normal psychometric intelligence and ...

Alopecia is an autoimmune disorder where immune cells attack and destroy hair follicles, causing hair loss. Uncovering a molecular target of a common treatment for alopecia in a new study, scientists ...