Glucosamine and chondroitin are the most well-known. Methyl sulfonylmethane (MSM) is another supplement used to ease the pain of arthritis, but it has not been through as much scientific testing.

A small number of foods do contain methylsulfonylmethane but only in very small amounts. Taking MSM in supplement form is a much easier way to increase your intake than looking to find it in foods.

MSM is sold alone and in multi-ingredient supplements, in the form of capsules, crystals and lotions. Precautions: MSM may have laxative effects and cause headaches or stomach pain.

By Korin Miller Published: Feb 21, 2025 12:25 PM EST ...

MSM is considered a pretty safe oral supplement to take, says Mary Bridgeman, PharmD, clinical professor in the Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey.

MSM is generally well tolerated, making it a popular choice for those seeking natural joint pain relief. However, like any supplement, it is not without potential side effects.

Supplements are available in most health stores and pharmacies in pill form. Toxicity studies suggest that MSM is safe to take in higher dosages, ranging from 500 milligrams to 3 grams daily.

Q: Years ago, I read in your column that MSM supplements (without glucosamine) helped hair stay full and thick. I started taking it about 2002, and I have pretty, thick, healthy hair at age 57. I ...

However, as with other supplements, there are some side effects to taking MSM. These include flatulence and diarrhoea. However, these symptoms can go away after a few days once the body adjusts.

MSM supplements may help with joint pain and swelling, but some experts aren't convinced. What you should know about how they work and who should take them.