Researchers have made a surprising discovery linking Delta/Notch signaling in subperineurial glia (SPG) to the regulation of nerve ensheathment and neurotransmitter release at the Drosophila ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Delta-like ligand-3 (DLL3) is a single-pass, type I transmembrane protein that inhibits the Notch signaling pathway. A highly conserved intercellular signaling pathway, the Notch signaling pathway ...

Prism Biolab Co. Ltd. has identified new 7-membered ring-fused compounds acting as Notch signaling inhibitors and reported to be potentially useful for the treatment of neuronal injury and ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

(A) The mRNA expression levels of Hey1 and Hes1 in each treatment group were measured by quantitative real-time PCR. (B) Western blot analysis of NICD expression in the cytoplasm and nucleus in each ...