This article examines some of the cell-based approaches that researchers are using to study acquired drug resistance and the effects of specific genetic variants on cancer cell physiology.

The problem of cell type became clear to genome biologist Jason Buenrostro in 2013. He was studying a cell line derived from someone with cancer, trying to map out how the DNA was arranged in the ...

U.S. government researchers have made a significant step forward in developing a fully automated process for cell-line development. The National Institute of Allergy and Infectious Diseases (NIAID), ...

Viral vector-based gene therapies hold immense promise for treating a multitude of diseases. However, their widespread adoption has been hindered by inefficient manufacturing methods and the absence ...

Cell culture is a fundamental technique in biotechnology and life sciences that involves growing and maintaining living cells outside their natural environment, typically in a controlled laboratory ...

This valuable study presents an analysis of the gene regulatory networks that contribute to tumour heterogeneity and tumor plasticity in Ewing sarcoma, with key implications for other fusion-driven ...