Central to this conversion is the synthesis of adenosine triphosphate (ATP) via mitochondrial ATP synthase complexes ... including the torsional mechanism and two‐ion models, offer a more ...

If1 inhibition of ATP hydrolysis by the mitochondrial F0F1-ATP synthase is key to stabilize the free F1 subcomplex. If1 is crucial in mitigating mitochondrial depolarizing stress under glyco-oxidative ...

This month's cover highlights the article Epicardial VEGFC/D signaling is essential for coronary lymphangiogenesis by Miguel Torres, Ester de la Cruz and colleagues. The image shows a mouse ...

This new concept regarding the mechanism of dephosphorylation is also supported ... Several KaiCII residues play a critical role in the relative activities of kinase and ATP synthase, among them R385, ...

Research Center for Computational Science, Institute for Molecular Science, National Institutes of Natural Sciences, Okazaki, Aichi 444-8585, Japan Graduate Institute for Advanced Studies, SOKENDAI, ...

"Despite decades of research into ER function, the question of how ATP reaches the inside of the ER has been unclear. By confirming SLC35B1 as the transporter and resolving its structure with cryo ...

This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...

Experiments showed that lowering cysteine levels caused a drop in levels of the small molecule called coenzyme A (CoA), which rendered inefficient mechanisms that convert carbohydrates and fats ...

Jonathan Whittall, head of the UN Office for the Coordination of Humanitarian Affairs (OCHA) in the West Bank and Gaza, criticizes the new aid distribution mechanism in the Gaza Strip initiated by ...

This study presents compelling evidence that the denitrosylase SCoR2 regulates cardioprotective metabolic reprogramming in the heart following ischemia/reperfusion injury. The findings are supported ...

Duchen and Douglas C. Wallace) Cellular powerhouses called mitochondria generate fuel known as adenosine triphosphate, or ATP, to sustain complex life. The capacity of mitochondria to do so depends on ...