Generally, cytoskeletal proteins are polymers, and include tubulin (the protein component of microtubules), actin (the component of microfilaments) and lamin (the component of intermediate filaments).

Copper supplementation impaired the β-tubulin and F-actin networks. Copper chelation resulted in the decrease of F-actin content in dendrites, drastically reducing the number of F-actin protrusions.

The mechanical and structural properties of actin filaments play critical roles in various cellular functions, including structural support, cell movement, division, and intracellular transport.

Tubulin posttranslational modifications have been predicted to control cytoskeletal functions by coordinating the molecular interactions between microtubules and their associating proteins. A ...

Calcium signals cause calcium−calmodulin to activate CaMKII, which leads to remodeling of the actin filament (F-actin) network in the spine. We elucidate the mechanism of the remodeling by combining ...

Dr. Tsuneya Ikezu cloned a neuron-specific tau kinase — tau-tubulin kinase 1 (TTBK1) — from the human brain tissue cDNA library and characterized the role of TTBK1 in tau aggregation in the context of ...