Primary B cells showed upregulation of multiple phosphoproteins upon DuoHexaBody-CD37 treatment including p-AKT, p-FAK, p-Src and p-Shc ... cells rely on other oncogenic signaling pathways (i.e.

Inhibiting RMB42 disrupted production of Myc proteins in pancreatic cancer cells. This approach could curtail the growth of several cancer types. A review paper published last year in European ...

Washington Times' Susan Ferrechio and Vox's Andrew Prokop discuss President Trump's first 100 days in office and Center for a New American Security's Jim Townsend discusses the Russia-Ukraine war ...

Rep. Bill Foster (D-IL) held a town hall in McHenry County, Illinois to hear from constituents in his district. They raised concerns around tariffs, social security, DOGE cuts to federal agencies ...

In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

Mechanistically, targeting DUSP22 suppressed FOXO3a, a master regulator of skeletal muscle wasting, via downregulation of the stress-activated kinase JNK, which occurred independently of aberrant Akt ...

Circular RNAs (circRNAs) have been gradually revealed to regulate the progression of heart disease in depth, showing their clinical significance. However, a mass of cardiac circRNAs still has not been ...

Mechanistically, SNRPB2 activated genes associated with the β-catenin/c-Myc signaling pathway, such as β-catenin, c-Myc, CCNA2, CCNB1, CDK1, and CDK2. This activation also regulated the ...

Recent studies have identified the reprogramming of lipid metabolism as a critical hallmark of malignancy. Enhanced cholesterol uptake and increased cholesterol biosynthesis significantly contribute ...