53BP1 is a key player in DNA repair and together with BRCA1 regulate selection of DNA double strand ... order oligomers of 53BP1 explains how LC8 elicits an improvement in 53BP1 foci and affects the ...

041) and greater sMRD spatial dispersion interspersed with genomically undetected regions, while responders exhibited more compact disease foci (standard deviation ... including genes involved in DNA ...

A predominant mechanism of acquired PARP inhibitor resistance in HR-deficient cancers is the acquisition of HR proficiency as a consequence of secondary genetic or epigenetic events such as secondary ...

In women with BRCA1 mutations, hormonal contraceptives were associated with a significantly higher risk for breast cancer in a dose-response relationship, researchers reported in an observational ...

Kelly-Anne Phillips, Joanne Kotsopoulos, Susan Domchek, Mary Beth Terry, James Chamberlain, Julie Bassett, Amber Aeilts, Irene Andrulis, Saundra Buys, Wanda Cui, Mary ...

Breast cancer survivors carrying BRCA1 and BRCA2 gene variants had a 48% overall lower risk of death after undergoing the surgery, which is known as bilateral salpingo-oophorectomy (BSO ...

Fig 1. Radiographic findings. (A) Coronal T2-weighted image shows a small, ovoid right adrenal mass (white arrow) and larger, triangular left adrenal mass (black arrow) with heterogeneity and higher ...

TUESDAY, May 13, 2025 (HealthDay News) — For carriers of pathogenic variants in BRCA1 and BRCA2 with a personal history of breast cancer, bilateral salpingo-oophorectomy (BSO) is beneficial, resulting ...

A Galatasaray a magyar válogatott Sallai Rolanddal a kezdőcsapatban 3-0-ra legyőzte a Trabzonsport a labdarúgó Török Kupa szerdai döntőjében, ezzel megnyerte a trófeát. A 27 éves magyar futballista ...