Panelists discuss how the EMERALD trial demonstrated elacestrant's efficacy in ESR1-mutated tumors, particularly in patients who had received CDK4/6 inhibitors for at least 12 months. This led to its ...

Most readers would already be aware that INDUS Holding's (ETR:INH) stock increased significantly by 22% over the past three months. Given that stock prices are usually aligned with a company's ...

Our objective was to evaluate the efficacy of isoniazid in prevention of tuberculosis morbidity and mortality in children aged 15 years or younger by performing a meta-analysis of randomized ...

Edward Robitzek and Irving Selikoff of Sea View Hospital conducted clinical trials of the drug Isoniazid, the first drug to treat tuberculosis. Since its discovery, the drug has saved tens of ...

CDK4/6 inhibitor Verzenio (abemaciclib) was the third drug in the class to reach the market, first approved in 2017 as a second-line treatment for post-menopausal patients with hormone receptor ...

They were discovered accidentally when the tuberculosis drug, isoniazid, was found to lift the mood of patients suffering from TB. Antidepressant drugs such as isocarboxazid (Marplan), phenelzine ...

The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings per share from continuing operations ...

Structural Formulas of Hydralazine and Isoniazid. For these reasons, then, 2 patients in whom neuropathic symptoms had developed while they were receiving hydralazine were treated with pyridoxine ...

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.

Meihua Li and Apeng Liang contributed equally to this work. FDA approved CDK4/6 inhibition medicines has demonstrated significant clinical benefits in patients with HR+/HER2- breast cancer. However, ...