Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Kisqali works by blocking proteins called CDK4 and CDK6 that help cancer cells grow and divide. This is the drug’s mechanism of action (how it works). By blocking these proteins, Kisqali slows ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

Knives Out director Rian Johnson has shared insights about the future of the franchise, starring Daniel Craig in the lead. Rian, who has been acting as the director for the since its debut in 2019 ...

Colorectal cancer (CRC), or bowel cancer, includes colon cancer and rectal cancer. It involves the uncontrolled growth and division of cells in the colon or rectum. The colon is the longest ...

Get Instant Summarized Text (Gist) The herpesvirus protein UL13 mimics host cyclin-dependent kinases (CDKs), with phosphorylation at a conserved tyrosine residue downregulating its kinase activity ...

Americans’ confidence in the economy slumped for the fifth straight month to the lowest level since the onset of the COVID-19 pandemic as anxiety over the impact of tariffs takes a heavy toll ...