Bone-destructive diseases such as osteoporosis ... including immune system function and mammary gland development, drugs that broadly inhibit this pathway can cause diverse side effects.

If you have ever broken a bone, you quickly learn two things: it hurts a lot, and bones are living tissue that takes time to ...

While the embryonic limb bud expresses PDGFRα, its role during limb development is unknown. Here, the authors show that elevated PDGFRα signaling causes joint fusion in mice, as joint ...

Whether you are a competitive athlete or an older adult, strong bones are essential—not only for movement, but also for overall health. Now, a new study has shed new light on how our bones are ...

This is enough to downregulate the development of mature osteoclasts without affecting unrelated biological processes as a side effect. Bone-destructive diseases such as osteoporosis and chronic ...

Osteogenesis was always minimal in untreated defects whatever their size, and bone union never occurred (Fig. 1A, B). The bone-regenerating ability of the implants was subsequently evaluated using ...

Inc. and its partner global brand management firm WHP Global, which jointly owns the New York-based fashion brand rag & bone, announce a four-year exclusive licensee partnership with Marcolin - a ...

The years from childhood until age 30 are prime time for building bone mass. "If an adolescent is smoking, they will not develop maximum bone mass. They will end up with a smaller skeleton and ...

but can be pharmaceutically “turned off” to encourage bone development in conditions such as osteoporosis and OI. Regulators have already said the drug holds promise: in Europe it has been ...