This disruption fosters the upregulation of oncogenic regulators such as c-Myc and Cyclin D1, thereby accelerating HCC progression. Notably, the combination therapy involving all-trans retinoic ...

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.

Version of Record: This is the final version of the article. García-Vázquez et al. identify GTSE1 as a novel target of the cyclin D1-CDK4/6 kinases. The authors show that GTSE1 is phosphorylated at ...

Alan Diehl (2022) Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss. Oncogene 41, 2187-2195. * Co-corresponding author Akihiro Yoshida, ...

In a 286-patient Phase 2 trial, elraglusib combined with gemcitabine/nab-paclitaxel achieved a statistically significant ...

Case Western Reserve University, Cleveland, OH.

As vehicles have become more advanced, the code readers needed to follow, and now you can find truly impressive diagnostic tools, like the OTOFIX D1 Lite, a device that allows for a lot more ...

INDIANAPOLIS — Vanderbilt athletic director Candice Storey Lee, Missouri Valley Conference deputy commissioner Jill Redmond and Maryland interim athletic director Colleen Sorem have been ...

The Ohio State Buckeyes football program is consistently bringing in many of the best players in the country, making it difficult to get on the field. That's what TC Caffey realized after having ...

Southwestern shortstop Payton Swartz receives a throw on a stolen base attempt by Fredonia during Monday’s CCAA Division 1 softball game. P-J photo by Ashleigh Brown FREDONIA — Callie Draggett hit a ...