a “knock-in” model known as App-NL-G-F. To reduce the issue of tau overexpression, Watamura’s team further modified the mice by replacing their native mouse tau gene (sgRNA-MAPT-Exon10 P301) with its ...

Scientists have found that lemborexant not only increased restorative sleep in male mice but also reduced levels of toxic tau ...

A new study uncovers the long-elusive mechanism of inhalational anesthetics by identifying the RyR1 calcium channel as a key molecular target.

Both small animal models and microphysiological systems gain in sophistication and value as they expedite in vivo preclinical testing.

A research team at The University of Tokyo has discovered that inhalational anesthetics activate a protein called type 1 ryanodine receptor (RyR1), ...

Since their anesthetic effects were discovered approximately 180 years ago, inhalational anesthetics have been used for ...

Chimeric antigen receptor (CAR)-T cells are a promising cancer therapy that are made from the patient's own T cells, which ...

T cells are a promising cancer therapy that are made from the patient's own T cells, which are reprogrammed to fight their ...

BACKGROUND: Cardiac hypertrophy, as an important pathological change, contributes to heart failure. Recent studies indicate that the mitochondria-associated endoplasmic reticulum membranes (MAMs) play ...

Marcela Maus , MD, PhD, director of the Cellular Immunotherapy Program and the Paula J. O'Keeffe Endowed Chair of the Mass ...