Cell line studies showed that metformin inhibits hepatocyte proliferation and induces cell cycle arrest at G0/G1 phase via AMP-activated protein kinase and its upstream kinase LKB1 to upregulate ...

This valuable study provides insights into a key question in comparative neuroanatomy and development. The authors provide evidence of the role for a particular micro-RNA in regulating the development ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

Bayan Muna party-list said yesterday that the P21-billion ($375-million) BrahMos missile deal, initiated by the Duterte administration and now being implemented by the Marcos administration ...

In 2024, PAL recorded its fourth consecutive year of profitable operations with a net income of P10.2 billion, although this marked a 51 percent decline from its record-high net income of P21 ...

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.

Specifically, it upregulates p21 while downregulating cyclin E, cyclin D1, as well as the oncogenes c-Myc and Ras (137). In the context of viral infections, loss of IFI16 has been shown to impact ...

Background Myxomatous mitral valve disease (MMVD) is the most common age-dependent degenerative cardiovascular disease of the dog and an important valvulopathy in humans. It involves extra-cellular ...

National Cheng Kung Univ. Medical College, Tainan, Taiwan.