Inhibiting transcriptional mechanisms of resistance via CBP/p300 represents an exciting and much needed opportunity for more effective and tolerable therapies. TT125-802 has shown impressive ...

Inhibiting transcriptional mechanisms of resistance via CBP/p300 represents an exciting and much needed opportunity for more effective and tolerable therapies. TT125-802 has shown impressive activity ...

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To address these issues, we determined the structures of the p300 HAT domain in the prereaction conformation in complex with acetyl-CoA, in the postreaction conformation with CoA, and in an inhibited ...

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Figure 1: Structures of the TIR domain. The structures reveal that the core TIR domain starts from the conserved (F/Y)DA amino-acid motif and ends roughly eight residues carboxy-terminal to the ...

Gov. Kim Reynolds says she's finished meeting with supporters and opponents of a bill dealing with pipelines and eminent domain and she's "really close" to deciding whether she'll sign or veto it.

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