The AMPK/mTOR signaling pathway plays a crucial role in autophagy regulation ... 2023) demonstrated that BaP activates the p53-protein-interacting protein 3 (BNIP3) pathway via the aryl hydrocarbon ...

The role of EGFR in KRASG12D-driven tumorigenesis was studied using mouse CRC organoids with KRAS-APC-TP53 mutations and ...

Moringa oleifera - This plant's extracts induce apoptosis by enhancing p53 expression, a key tumor suppressor protein, and causing G2/M cell cycle arrest, making it a promising candidate for ...

We are investigating the mechanisms by which cancer mutations deregulate the normal processes of cellular function and growth ...

Major Finding: Dietary ω-6 linoleic acid (LA) promotes oncogenic mTOR signaling in triple-negative breast cancer (TNBC). Concept: TNBCs express the fatty acid binding protein FABP5, which senses ω-6 ...

This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of ...

NTS071 is an oral small molecule allosteric reactivator targeting p53 Y220C with a novel scaffold. It selectively binds to the p53 Y220C mutant protein, improving its thermal stability, thereby ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cells change their metabolic profiles in ...