Immuneering has reported 94% overall survival (OS) at six months in first-line pancreatic cancer, emboldening the biotech to ...

ERBB1 evolved into a transient stimulator of the Ras–mitogen-activated-protein-kinase pathway, whereas ERBB3 evolved into a strong, but non-autonomous, linker to the phosphatidylinositol-3 ...

Background Pathogenic mutations in genes encoding components of the Ras/mitogen-activated protein kinase (Ras-MAPK) pathway cause RASopathy. Here, we describe five unrelated patients with SLE carrying ...

Mitogen-activated protein kinase (MAPK) signaling pathways are important in regulating a variety of cellular processes 1. In the nervous system, both the p42/p44 and p38 MAPK pathways have been ...

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Pathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective ...

Researchers observed that these drugs act on key cellular communication pathways involved in the aging process. Rapamycin targets the mTOR protein, while trametinib interferes with the RAS/Mek/Erk ...

In summary, both a β1-activating antibody and flow stimulate tyrosine kinases, leading to activation of FAK and MAP kinase signal-transduction pathways. However, the cellular responses elicited by 8A2 ...