After encountering antigen in the periphery and under the influence of the cytokine milieu present, CD4 + T cells can further differentiate into subtypes, including Th1, Th2 and Th17. T cells seem ...

The initial decision concerning which type of T effector cell will be induced during an immune response is critical to the outcome of an infection. Interferon γ (IFN-γ)–producing T helper ...

We propose that anti-CTLA-4 therapy induces peripheral expansion of Th17 cells followed by IL-12–driven conversion into Th1-like effectors (Th17→Th1 plasticity). This dual process potentiates ...

ST2L was originally investigated as a cell-surface marker for a subclass of T-cell leukocytes, the type II T-helper (Th2) cell. More recently, ST2L has been shown to participate in activation of ...