Shenzhen Zhongge Biotechnology Co. Ltd. has described proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding agent coupled to interleukin-1 receptor-associated ...

When the cellular waste disposal system goes on strike, this can have fatal consequences. A research team at the University ...

Slow progress, pipeline uncertainty & lack of catalysts weigh despite strong cash. Click to read why KYMR stock is a Hold.

Researchers have discovered how to block cells dying, in a finding that could lead to new treatments for neurodegenerative ...

Scientists have developed a powerful new method for selectively and reversibly breaking connections between brain cells—a ...

Circadian disruption, seen with shift work, can have intrinsic and extrinsic effects on muscle health, contributing to muscle ...

Researchers have identified a small molecule that can selectively block cell death. The findings lay the groundwork for ...

Researchers have discovered how to block cells dying, in a finding that could lead to new treatments for neurodegenerative conditions like Parkinson's ...

Recent work shows that in rice, an E3 ubiquitin ligase senses viral coat proteins to activate the jasmonate signalling pathway by degrading NINJA3, and triggers downstream antiviral defence responses.

The authors demonstrate that nsp16 undergoes ubiquitination and subsequent degradation by the host E3 ubiquitin ligases UBR5 and MARCHF7 via the ubiquitin-proteasome system (UPS). Specifically, UBR5 ...

Samples enriched for proteins were analyzed by mass spectrometry. Figure 2. MARCHF7 and UBR5 were identified as E3 ubiquitin ligases involves in nsp16 protein degradation. A. Knockdown of MARCHF7 or ...

Department of Science and Mathematics, Rochester Institute of Technology/NTID, Rochester, New York 14623, United States ...