leading to reduced expression of the Wnt/β-catenin signaling inhibitor WIF-1 via RARs/RXRs-mediated mechanisms. This disruption fosters the upregulation of oncogenic regulators such as c-Myc and ...

10:15 a.m. to 12:15 p.m. “Multi-omics analysis of MYC gene and WNT signaling pathway alterations in early-onset colorectal cancer in Hispanic/Latino patients, enhanced with spatial ...

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell differentiation and reducing tumor growth.

While ATRTs are known to segregate into three epigenetically defined subgroups, termed SHH, TYR, and MYC, little is known about the cellular ... in radial glial and mesenchymal signalling, such as WNT ...

In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further ...

Inhibiting RMB42 disrupted production of Myc proteins in pancreatic cancer cells. This approach could curtail the growth of several cancer types. A review paper published last year in European ...

Muir is the anchor and managing editor of "World News Tonight with David Muir." David Muir, the anchor and managing editor of America's most-watched newscast "ABC's World News Tonight with David ...

"He shows up calm, respectful, and fearless," Sawyer said of Muir. David Muir, who was named in the TIME100 Most Influential People of the year, received a touching tribute written by fellow ABC ...