The HER3-directed ADC will be tested in patients whose disease had progressed despite earlier treatment with EGFR inhibitors, including third-generation drugs like AZ's Tagrisso (osimertinib).

In acute kidney injury, certain biomarkers—such as urine albumin-to-creatinine ratio and epidermal growth factor—are linked with likelihood of eGFR nonrecovery. Serum creatinine elevations during ...