Various gene silencing technologies like siRNA, miRNA, ribozymes, DNAzymes have shown promise as therapeutics agents against viral diseases. RNAi-based drugs against viruses such as ebola virus ...

Various gene silencing technologies like siRNA, miRNA, ribozymes, DNAzymes have shown promise as therapeutics agents against viral diseases. RNAi-based drugs against viruses such as ebola virus ...

Smith et al. use clinical development screen and whole genome siRNA-reverse genetics phenotypic screen to identify ROCK2, as a modulator of cilia formation and function via its effects on actin ...

Four hundred nanograms of total RNA were hybridized on GeneChip microRNA array (Affymetrix ... silencing in K562 cell line was realized using siRNA (siRNA-14q(II-1), Sigma; siRNA-negative control ...

Owing to the growing need for new drug classes, demand for oligonucleotide APIs is projected to rise at a high CAGR of 5.60% from 2024 to 2034. As such, the global oligonucleotide API market is ...

Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States ...

Small RNA molecules, such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), are critical regulators that orchestrate ...

The US biotech has just reported phase 2 trial results with the small, interfering RNA (siRNA) gene-silencing drug showing that it an cause a 90% or greater reduction in Lp(a) levels – a risk ...

Final results of the OCEAN(a)-DOSE trial – published in the New England Journal of Medicine – showed that the small, interfering RNA (siRNA) drug reduced Lp(a) levels compared to placebo at ...

Glioblastoma multiforme (GBM) is the most common type of primary brain tumor in adults and has a poor prognosis. Small interfering RNA (siRNA) can disrupt different mechanisms involved in the genesis ...

This study explored the roles of microRNA (miRNA)-214, which targets the NCKAP1 gene, in the progression of ALS. Methods The discovery cohort (n=29) was used to identify miR-214 targeting NCKAP1 genes ...